The Office of Nuclear Physics (NP), Office of Science (SC), U.S. Department of Energy (DOE), hereby announces its interest in receiving applications for Research and Development (R&D) on alternative methods to produce radioactive and enriched stable isotopes needed for a wide variety of research and applications. This announcement is administered under the NP Isotope Development & Production for Research and Applications (IDPRA) Sub-Program. The proposed research and development should generate data or lead to new and innovative technologies, or improvements to existing technologies, to foster enhanced production of isotopes. Successful proposals will describe how the outcome of the proposed work would support and enhance research and applications using isotopes in medicine, homeland security, the physical sciences, biological and geological sciences, energy, industry, etc. Applications proposing novel and effective ways to train and develop personnel with knowledge and skills related to the production, processing, purification, and distribution of enriched stable and radioactive isotopes are encouraged. A companion Program Announcement to DOE National Laboratories (LAB 14-1099) may be found on the SC Grants and Contracts web site at: http://www.science.energy.gov/grants. Proposals submitted to this FOA will be evaluated competitively with those submitted to the Laboratory companion announcement.