The Advanced Manufacturing Office (AMO) seeks information on mid-Technology Readiness Level (TRL) research and development (R&D) needs, market challenges, supply chain challenges and shared facility needs in addressing advanced manufacturing development challenges impacting clean energy manufacturing. AMO is particularly interested in the challenges associated with advanced manufacturing technology which might be overcome by pre-competitive collaborations conducted via a Clean Energy Manufacturing Innovation Institute. AMO recently completed a broad RFI on this topic area. The intent of this RFI is to narrow the focus of a possible Clean Energy Manufacturing Institute and invite discussion on a set of the following specific focus areas. The Topical/Technical Focus Areas under consideration in this RFI are: Advanced Materials Manufacturing (AMM); Advanced Sensing, Control, and Platforms for Manufacturing (ASCPM); High-Efficiency Modular Chemica l Processes (HEMCP); and High Value Roll-to-Roll Manufacturing (R2R). Information on where to submit questions regarding the content of the announcement and where to submit questions regarding submission of responses can be found in the full RFI posted on the EERE Exchange website at https://eere-exchange.energy.gov. THIS RFI IS NOT A FUNDING OPPORTUNITY ANNOUNCEMENT (FOA); THEREFORE, DOE IS NOT ACCEPTING APPLICATIONS.