Applications to the Fiscal Year 2014 (FY14) Clinical and Rehabilitative Medicine Research Program (CRMRP) are being solicited for the Assistant Secretary of Defense for Health Affairs, Defense Health Program (DHP), by the U.S. Army Medical Research Acquisition Activity (USAMRAA). The goal of the CRMRP is to fund innovative projects that have the potential to make a significant impact on improving the function, wellness, and overall quality of life for injured military Service Members and Veterans, their caregivers and family members, and the American public. The CRMRP challenges the scientific community to design innovative research that will foster new directions for and address neglected issues in the field of reconstructive transplantation (RT), specifically vascularized composite allotransplantation (VCA)-focused research, also known as composite tissue allotransplantation (CTA). VCA refers to the transplantation of multiple tissues such as muscle, bone, nerve, and skin, as a functional unit (e.g., a hand, or face) from a deceased donor to a recipient with a severe injury. Applications from investigators within the military Services and applications involving multidisciplinary collaborations among academia, industry, the military Services, the Department of Veterans Affairs (VA), and other Federal Government agencies are highly encouraged. Though the RTR Award mechanism supports groundbreaking research, all projects must demonstrate solid scientific rationale with military-relevant utility. The FY14 RTR Award mechanism will give special consideration to projects aimed at modifying or restructuring clinical practice guidelines and projects intended to bring research findings rapidly into clinical practice. Investigators are encouraged to consider adaptation of approaches utilized in solid organ transplantation for standardization of processes and protocols. The intent of the FY14 RTR Award is to support projects that will accelerate the movement of promising ideas in RT into clinical application. The mechanism is intended to support both new and established scientists across a broad spectrum of disciplines in research projects that are likely to have a major impact on RT.