This initiative is funded through the NIH Common Fund, which supports cross-cutting programs that are expected to have exceptionally high impact. All Common Fund initiatives invite investigators to develop bold, innovative, and often risky approaches to address problems that may seem intractable or to seize new opportunities that offer the potential for rapid progress. This U24 Cooperative Agreement Funding Opportunity Announcement (FOA) will support the NIH Science of Behavior Change (SOBC) Resource and Coordinating Center (RCC), which will coordinate the activities of between five and nine UH2/UH3 Target Validation Projects. The initial UH2/UH3 awards will be made in response to three companion FOAs (RFA-RM-14-018, RFA-RM-14-019, RFA-RM-14-020) that will focus on identifying and validating targets in the three specific behavioral domains of self-regulation, stress reactivity and stress resilience, and interpersonal and social processes. The overall goal of the SOBC Program is to transform behavioral intervention designs by implementing the experimental medicine approach to behavior change research. The overall goal of the RCC will be to provide national leadership for the coordinated efforts of projects and initiatives of SOBC to validate assays for behavior change, with five specific objectives described in this FOA. The RCC will also serve as the central resource for the organization of the meetings and other activities of the SOBC program, including the support of its Steering Committee and External Scientific Panel, and any SOBC steering committee subcommittees that are established. Please refer to the SOBC website regularly for updates, frequently asked questions (FAQs), and other announcements related to this FOA and the companion FOAs. SOBC Website: http://www.commonfund.nih.gov/behaviorchange/ FAQs: http://www.commonfund.nih.gov/behaviorchange/faq/