Methods Development for Obtaining Comprehensive Genomic Information from Human Specimens that are Easy to Collect and Store (R43/R44)

 

This FOA invites applications to develop sensitive technologies or methods for obtaining high quality and comprehensive nucleic acids-based genomic data from limited quantities of human specimens that are easy to collect, handle, and store. Applications that address all of the steps from the collection of specimens, through storage and nucleic acids extraction, to obtaining genomic data will be considered as having highest priority to this FOA. The ease of proposed sample collection methods should be at least comparable to that of the current dried blood spot collection method. The developed technologies or methods should be applicable to clinical point-of-care testing in terms of speed and ease, and ultimately have the potential to be scalable to high throughput settings, while maintaining cost effectiveness. The genomic data obtained must be at least equivalent to that which can be obtained from fresh whole blood in terms of quality and comprehensiveness. It is expected that the research conducted under this FOA will enhance the availability of comprehensive nucleic acids-based genomic data for various clinical and research applications in need of obtaining genomic data from easy-to-collect and handle human specimens.

Active PAR-13-203 Agency: Department of Health and Human Services
Office: National Institutes of Health Grant Other Eligible Applicants include the following: Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, may be allowed. 03/25/2016 This program does not have cost sharing or matching requirements. NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV
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