Imaging Diagnostics of Dental Diseases and Conditions (Caries, Periodontal Disease, Cracked Teeth, and Pulp Vitality) [SBIR R43/R44]
The intent of this SBIR initiative is to accelerate the advanced development and clinical implementation of reliable, reproducible, highly specific and sensitive imaging diagnostic devices for dental caries, periodontal disease, cracked teeth, and pulp vitality. These new devices must demonstrate superior specificity and sensitivity compared with current diagnostic methods, such as the visual/tactile/radiographic examination for detection of caries, while not increasing health risks for patients. Approaches that could be explored include, but are not limited to: optical coherence tomography (OCT) with or without Raman spectroscopy, MRI image analysis, electrical conductivity measurement (ECM), quantitative laser fluorescence (QLF), alternating current impedance spectroscopy, multi-photon imaging, infrared thermography, infrared fluorescence (IR), ultrasound, and terahertz imaging. The development of novel modalities is also encouraged.
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