The Office of Science of the Department of Energy hereby announces its continuing interest in receiving grant applications for support of work in the following program areas: Advanced Scientific Computing Research, Basic Energy Sciences, Biological and Environmental Research, Fusion Energy Sciences, High Energy Physics, Nuclear Physics, and Workforce Development for Teachers and Scientists. On September 3, 1992, DOE published in the Federal Register the Office of Energy Research Financial Assistance Program (now called the Office of Science Financial Assistance Program), 10 CFR Part 605, Final Rule, which contained a solicitation for this program. Information about submission of applications, eligibility, limitations, evaluation and selection processes and other policies and procedures are specified in 10 CFR Part 605. This Funding Opportunity Announcement (FOA), DE-FOA-0000768, is our annual, broad, open solicitation that covers all of the research areas in the Office of Science and is open throughout the Fiscal Year. This FOA will remain open until September 30, 2013, 11:59 PM Eastern Time, or until it is succeeded by another issuance, whichever occurs first. This annual FOA DE-FOA-0000768 succeeds FOA DE-FOA-0000600, which was published September 30, 2011.