The PRORP Clinical Trial Development Award (CTDA) is intended to support the planning and development activities necessary to support preparation for clinical trials with the potential to have a significant impact on military combat-related orthopaedic injuries. The clinical trials proposed may be focused on any aspect of treatment of combat-related orthopaedic injuries that addresses the FY13 PRORP CTDA Focus Areas outlined below, including the evaluation of promising new products, pharmacologic agents (drugs or biologics), devices, clinical guidance, and/or emerging approaches and technologies. All applications are required to justify the relevance of the proposed project to military and/or Veteran populations affected by combat-related orthopaedic injury. Collaboration with military researchers and clinicians is encouraged, and studies that plan to include active duty military or Veteran participants as all or a portion of the study population will be given higher priority for funding during programmatic review.