The vision of the FY13 NFRP is to decrease the clinical impact of NF. Toward this end, the NFRP seeks to: support innovative, high-impact research that will foster new directions for and address neglected issues in NF research; sponsor multidisciplinary and multi-institutional collaborations that will bring new perspectives to the field; foster the next generation of NF investigators; promote translational and clinical studies to move promising ideas from bench to bedside; develop a balanced portfolio of meritorious research related to all aspects of NF1, NF2, and schwannomatosis. Areas of Emphasis: The FY13 NFRP strongly encourages research applications that specifically address the critical needs of the NF community in one or more of the following Areas of Emphasis: • Cognitive and social dysfunction in the setting of NF; • Drug discovery for the treatment of NF; • Heterogeneity of neurofibromas and other NF-related tumors using genomics, epigenetics, systems biology, or other similar approaches; • Manifestations of NF post-adolescence; • Novel disease markers such as imaging and proteomics of NF; • Pain in the setting of NF. The NFRP Investigator-Initiated Research Award supports innovative basic and clinically oriented research that will: • Provide insight into the development of NF, or into particular lesions or abnormalities that occur as a result of NF; • Result in substantial improvements over today’s approach to the diagnosis and treatment of NF; and • Have an impact on the quality of life of persons with NF. Applications must include preliminary or published data that is relevant to NF and the proposed research project.