The FY13 VRP Hypothesis Development Award (HDA) mechanism supports conceptually innovative, high-risk/high-reward research that could ultimately lead to critical discoveries or major advancements that will drive the field of vision research forward. Research projects should include a testable hypothesis based on a strong scientific rationale. This award is not intended to support the continuation of existing studies or the next logical extension and/or incremental step. The HDA is designed to support innovative ideas with the potential to yield impactful data and new avenues of investigation. Important aspects of the HDA are as follows: • Impact: The proposed research is expected to make an important and original contribution to advancing the understanding of visual dysfunction and lead ultimately to improved outcomes for patients. • Innovation: Research deemed innovative may represent a new paradigm, challenge existing paradigms, look at existing problems from new perspectives, or exhibit other uniquely creative qualities. Research may be innovative in study concept, research methods or technology, or adaptations of existing methods or technologies. Research that represents an incremental advance on previously published work is not considered innovative. The presentation of preliminary or published data relevant to one or more of the VRP HDA Focus Areas is encouraged, but NOT REQUIRED. It is the responsibility of the Principal Investigator (PI) to clearly and explicitly articulate how the proposed research project is innovative. To meet the intent of the FY13 VRP HDA mechanism, all applications must specifically address one or more of the FY13 VRP HDA Focus Areas listed below. Applications proposing research outside of the Focus Areas listed below should not be submitted in response to this Program Announcement/Funding Opportunity. • Mitigation and treatment of traumatic injuries, war-related injuries, and diseases to ocular structures and the visual system • Mitigation and treatment of visual dysfunction associated with traumatic brain injury (TBI) • Vision restoration following traumatic injury • Modeling and simulation of traumatic ocular injury