Purpose. The primary purpose of the AHRQ Patient Centered Outcomes Research (PCOR) Pathway to Independence Award (K99/R00) program is to increase and maintain a strong cohort of new and talented AHRQ-supported independent investigators trained in comparative effectiveness methods to conduct patient care outcomes research. The program is designed to facilitate a timely transition from a junior non-tenure track faculty or a postdoctoral research position (or their equivalents) to a stable independent research career. The program targets investigators early in their careers to support their development in new sophisticated methodological comparative effectiveness research skills, interdisciplinary perspectives, and capabilities in PCOR. Mechanism of Support. This FOA will utilize the K99/R00 award mechanism. Funds Available and Anticipated Number of Awards. Approximately $1.5 million will be available to support the K99 phase of the award and $3 million for the R00 phase. It is anticipated that AHRQ will make approximately 10 awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. The total amount awarded and the number of awards will depend upon the quality, duration and costs of the applications received.