The Collaborative Research on Addiction at the NIH (CRAN) composed of the National Institute on Drug Abuse (NIDA), the National Institute on Alcohol Abuse and Alcoholism (NIAAA), the National Cancer Institute (NCI), and along with the Eunice Kennedy Shriver Institute of Child Health and Human Development (NICHD), the National Institute of Mental Health (NIMH), the National Institute on Minority Health and Health Disparities (NIMHD), and the Office of Behavioral and Social Sciences Research (OBSSR) intend to jointly fund the Adolescent Brain Cognitive Development (ABCD) Study Consortium using the cooperative agreement award mechanism. The objective of the consortium is to establish a national, multisite, longitudinal cohort study to prospectively examine the neurodevelopmental and behavioral effects of substance use from early adolescence (approximately age 9-10) through the period of risk for substance use and substance use disorders. The structure of the consortium shall consist of three highly integrated components that may be linked at the time of submission: (1) a set of Research Project Sites, (2) a single central Data Analysis and Informatics Center, and (3) a single overall Coordinating Center. Unlinked applications will also be accepted, and if selected for funding, will be linked to other applications to form a consortium after review. This Funding Opportunity Announcement (FOA) solicits applications for a single central Data Analysis and Informatics Center. This FOA runs in parallel with companion FOAs that solicit applications for Research Project Sites (RFA-DA-15-015) and a single overall Coordinating Center (RFA-DA-15-014). It is expected that investigators upon funding will work jointly with NIH scientific staff to assist, guide, coordinate, or participate in project activities.